In the present study it has been endeavored to estimate the fatigue crack propagation in V-notch Charpy specimens of 2024 T351 Al-alloy. For this purpose, a new application of fatigue crack growth (FCG) is developed based on the “Gamma function.” Experimental fatigue tests are conducted for stress ratios from 0.1 to 0.5 under constant amplitude loading. The empiric model depends principally on physical parameters and materials’ properties in non-dimensional form. Deviation percentage, prediction ratio, and band error are used for validation of the performance of the fatigue life. The results determined from Gamma application are in good agreement with experimental FCG rates and those obtained from using Paris law.