The 'H (270,400 MHz) and I3C (22.5,67.5 MHz) NMR spectra of a series of 2,3-3,5-and 3,6-dimethyl-3-(mhydroxy-/m-methoxy-pheny1)piperidines of proven or potential opioid ligand activity are reported. The data were analysed in terms of configuration and preferred conformation, and some key deductions were confirmed by NOED and 2 D COSY experiments. In the 3,5-dimethyl derivatives, isomers with preferred axial or equatorial 3-aryl substituents were identified.
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