WAT is where triglyceride is stored primarily storage, while BAT is specified for energy spending and has the ability to offset obesity [5,6] . There are two types isolated from subcutaneous fat: cultured/relatively homogeneous adipose-derived stromal/stem cells (ASCs), and cultured/ heterogeneous stromal vascular fraction (SVF) cells [7] .Choukroun et al [8] was the first to report that Platelet Rich Fibrin (PRF) can be used in maxillofacial surgery. Platelet-rich fibrin (PRF) is formed when platelet cytokines, platelets and growth factors entrapped in fibrin meshwork [9] .The entrapped growth factors contribute in wound healing with many factors like collagen production, blood vessels growth, cell mitosis, recruitment of other cells migrating to the injury site, and cell differentiation induction [10,11] . When Mazor et al. [12] used PRF only as a filling in sinus lifting procedure, considerable bone has been detected in the sinus cavity.Despite being the gold standard for treatment of large bone defects, the autologous bone grafting may bear complications such as, donor site compromise, patient discomfort, and risk of graft resorption as well as dislodgement [3,[13][14][15] .