Digital Transformation has become one of the most discussed debates; many sectors have adopted digital transformation to gain a competitive advantage and to ensure their continuity. Moroccan universities, in their turn, are facing strategic and managerial challenges due to emerging practices related to digital transformation. To address this issue, the proposed work sets out to define the factors that lead us to adopt a digital transformation using SWOT analysis and to apply total quality management techniques to contribute to our research laboratory's digital transformation, by digitalizing and managing knowledge and processes. KMS-TQM digital platform has been used to capitalize knowledge and profile the different existing functions, positions, tasks, and referential competencies. Then, we analyzed all the actual processes to propose a business process re-engineering using Bizagi Modeler. The study's contribution is to standardize all the current processes in the laboratory to help the Doctoral Studies Center successfully carry out the digital transformation. Moreover, the aim is to make all functions and tasks for each position explicit.