Background: Tobacco has a high level of carcinogenic components. The maximum effect of the component is on the oral cavity and the location of tobacco. Quantitative studies were conducted according to the oral effect of tobacco usage by people of the south of Iran, specifically in Hormozgan province. In this experiment, the prevalence of oral lesions was studied in people who use tobacco in Hormozgan province in 2018. Materials and Methods: In this descriptive cross-sectional study, 395 patients were examined on oral lesions in Hormozgan province. Data were collected and described by a mean frequency table and then analyzed by an inferential statistical test such as the 2-dimensional chi-square test by SPSS, version 23 (P<0.05). Results: Experiments showed that 75.5% (299 from 395) of patients had mucosal lesions. The most lesions were tobacco pouch, wound, white plaque, and erythematic lesions. In addition, a significant correlation was found among parameters, including all mucosal lesions with time, all mucosal lesions with age (except wound), white plaque and erythematic mucosal lesions with smoking, tobacco pouch, and white plaque with alcohol use. However, no significant correlation was observed between oral mucosal lesions with a history of family oral lesions, tobacco pouch and wound with cigarette usage, and wound and erythematic lesions with alcohol use. Conclusion: Compared with other studies, oral mucosal lesions were highly prevalent in Hormozgan province. The possibility of oral mucosal lesions increases as one gets older; in addition, the duration of tobacco usage is a primary factor for the lesions.