Background Nowadays by the indiscriminate use of antibiotics, multi-drug resistant pathogens (MDR) developed and spread, so searching for effective natural antimicrobials is of global concern. Apitherapy possessing various therapeutic activities (antimicrobial, 1,2 anti-inflammatory, 3-5 antioxidant, 6-9 antiproliferative, 10 immunomodulator 11 ameloirative 12,13 or wound healing factor) 14,15 proved to be a suitable tool to get the target since it is very safe, highly effective, easily applicable and extremely economic. The subject is of interesting concept for the apitherapy research team affiliating to