Nowadays the covid-19 has created number of problem for effectives of global supply chain and in this situation only the strategic supplier partnership can help to address this global issue especially in context of developing country. In the present study primary data is collected through adopted questionnaire from previous studies. There are 200 respondents are considered from manufacturing companies of Sindh, Pakistan, who directly involve the supply chain management functions including procurement, operation and logistics management. Results of this study confirmed the partial mediation between strategic supplier partnership and responsive supply chain in the presence of e-procurement as a mediating variable. In previous studies research scholars find out the direct relationship between strategic supplier partnership and responsive supply chain. However, in this study mediating effect has been checked in presence of mediator e-procurement.