This study examines how to support regional development with the quadruple helix creative industry model through descriptive qualitative analysis. The primary data were collected through observation, interviews, and FGDs (Focus Group Discussions) with academics, creative economy actors, community leaders, and government officials. The markets in Medan, North Sumatra, Indonesia were studied between October 2020 and October 2021. Purposive sampling technique was used to select informants, and snowball sampling approach was utilized to conduct the interviews. The findings revealed that the lack of roles in research and knowledge production by academic actors in Medan has increased the need for a network of academic actors to fill the gap; the government has not been able to play a role in providing funding support and incentives for business actors in creative industries, especially in creating innovations. The synergy between actors in the quadruple helix implementation has not been properly utilized, even in the case of the Medan City Government, which ought to be the main source of information in social media for the city's creative sector. Following up on these findings, the quadruple helix creative industry model was implemented as an innovation model to support the regional economy of the city of Medan.