If left untreated, craniosynostosis can cause neuropsychological impairments, psychosocial problems, and craniofacial deformities. Its association with epileptic seizures is unknown. This review investigated the incidence of epilepsy in patients with craniosynostosis. The Cochrane Library, Science Direct, Web of Science, EBSCO, and PubMed were all searched. Rayyan QCRI was used to filter study article titles and abstracts before full-text evaluations were conducted. In total, 11 studies involving 21456 patients with craniosynostosis were examined; more than half of the patients were men. The highest reported rate of preoperative epileptic seizures was 12.2%, and the lowest rate was 2.5%. The highest rate of post-operative epilepsy was 12.2%, and the lowest was 0.24%. There is a lack of literature on epileptic seizures as an outcome among craniosynostosis patients. The metabolic or hemodynamic events following craniosynostosis corrective surgeries were more significant. However, neurological manifestations, including epilepsy, require close monitoring. We found that syndromic craniosynostosis patients experienced more significant problems than non-syndromic patients.

Children frequently experience status epilepticus (SE), a neurologic emergency. Based on current findings in the medical literature, this systematic review aimed to review the published literature of the updates in epidemiology of Status epilepticus in pediatric patients in Saudi Arabia. Because they are reliable sources, PubMed and EBSCO Information Services will be used as the search databases for the publications used in the study. Status epilepticus (SE), seizures, mental health issues, and GABA receptor were among the topics that should have been covered in the project, so those papers were chosen based on their applicability. A total of 105 studies were found after searching the aforementioned databases, which were then used for title screening. 32 of them were excluded after 63 of them were included for abstract screening. The full texts of the remaining 31 publications were examined. Seven studies were enrolled for final data extraction, which includes 23 papers that were excluded as a result of the full-text revision. SE is a complex neurological condition that is primarily seen in children and older individuals, two separate age groups. As the second most prevalent neurological disorder to result in death, it has a high mortality and morbidity rate. Concerning the cause of SE an electrolyte imbalance and febrile seizures were the two most frequent causes of convulsive status epilepticus, respectively. The diagnosis is based mainly on ECG, where children who have SE show abnormalities in their imaging. Management of the condition mainly using antiseizure medications such as Midazolam, lorazepam, and diazepam with almost similar efficacy.