-immunization is an attempt to confer immunity in infants and children by incorporating the vaccine into the body so that the body makes antibodies body prevent certain diseases. Immunization coverage in 2014 as much (89.78%) decreased compared to previous years, this was due to their socio-cultural factors or incorrect understanding on some of the mothers in the area of Medan Denai, as well as a lack of utilization of health services, especially immunization. This study was descriptive correlative aims to determine the relationship between the social and cultural factors with the willingness of mothers to bring their babies for immunization in Medan Denai Community Health Centre. A 100 Family as a respondent were interviewed. Study found that majority of respondents had high school, and the results showed statistically that there is a significant relationship between education and the willingness to bring their children for immunization, respondents did not work (Housewife), showed statistically that there is no significant relationship between education and the willingness to bring their children for immunization, high-income respondents and the result showed statistically that there is no significant relationship between education and the willingness to bring their children for immunization, majority of respondents have Culturally appropriate showed statistically that there is a significant relationship between education and the willingness to bring their children for immunization, majority of respondents have confidence that appropriate and statistically significant relationship between education and the willingness to bring their children for immunization, majority of respondents in a good knowledge statistically significant between education and the willingness to bring their children for immunization. Expected that the Community Health Centre in Tegal Sari district, Medan Denai to improving health care in their working area, especially in terms of preventive and promotive through education about the importance of immunization by immunization workers and Posyandu cadres.