S ince last two decades the work on oleogels is being exploited in pharmaceutical, cosmetics, and nutraceutical industries for their desired rheological, physical, and chemical stabilities in semisolid formulations. Recently, we had developed a stable and efficacious oleogel containing diclofenac diethylamine for topical application. The present review article deals with the literature of oleogels including its application in various fields from last few decades till date. The literature reveals that the oleogels have simplicity in manufacturing, high physical, chemical, and mechanical stability and better invivo efficacy, which make them appropriate to employ as bases for topical formulations.

The aim of this paper was to describe the use of a 2-hydroxypropyl beta-cyclodextrin (2-HP CD) as a tool to improve the chemical stability of tiagabine hydrochloride (TGB). HPLC method was used to quantify TGB. The correlation coefficient of the linearity (r 2 ) of HPLC method was more than 0.999 whilst the limit of detection and the limit of quantification of TGB were 0.6494 g ml -1 and 1.765 g ml -1 respectively. The effect of 2-HP CD on the chemical stability of TGB was compared with -tocopherol and ascorbic acid, the most recognized antioxidants used to enhance the stability of TGB. The stability was expressed by (% w/w) of the total related substances (TRS) of TGB. When TGB was exposed for 24 h to 50°C, the TRS were 3.264% (SD ±0.077) and 3.125% (SD ±0.053) in the presence of -tocopherol and ascorbic acid, respectively. The TRS of TGB complexed with 2-HP CD was 2.142% (SD ±0.045). This study demonstrates that 2-HP CD exhibits an obvious enhancement of TGB chemical stability with a different mechanism compared with the usual antioxidants.

Nine degradation products of TGB were identified. Some diagnostic MS/MS product ions, characteristic of the piperidine or thiophene moiety, were highlighted.

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