Background/objectives: In this age of Internet, knowledge about how to best use Information and Communication Technology (ICT) is the key to the success of any business, or an organisational entity, including non-profits, irrespective of size and sector. Non-profit organisations (NPOs) can also benefit from the latest technological advancements in the field of information technology. Methods/statistical analysis: We found there was a clear lack of research that evaluates the impact of knowledge management (KM) tools on decision support system (DSS) specific to NPOs, and we wanted to identify and recommend the various ways such a support system can be developed to help NPOs become more competitive and successful in their endeavours, which is the core objective and motivation behind this research work. There is an immediate and critical requirement to make NPOs understand the impact and benefits of staying up-to-date with technologies such as KM tools and develop and implement a DSS that will help strengthen and optimise the organisation's business operations. Findings: The primary objective of this article is to critically evaluate the impact of KM tools on DSS in an NPO. Due to the complexity of the research topic, and the amount of theories, ideas, and strategies already proposed, a qualitative research approach has been adopted to collect primary data. Experts in the field of KM and DSS having work experience in NPOs were carefully selected for interviews using snowball and criterion sampling. The key findings of this research are that competition does exist even in the NPO sector, and NPOs must take necessary strategic decisions to sustain themselves and grow strongly in this highly competitive market. Improvements/applications: The other main findings of this research are that KM has a huge impact on DSS, and DSS plays a pivotal role in making the NPO more competitive in its field(s).