Background: Third molars are the last to erupt in the permanent teeth series. These teeth are the most likely to be impacted this research aims to evaluate whether the distance between mandibular retromolar foramen and mandibular angle renders different results in case of absence or presence of lower third molar in both genders.Methods: A respective study conducted on 186 the distance between mandibular retromolar foramen and mandibular angle were examined on Digital panoramic radiograph (DPR). The radiographs were grouped according to Absence or presence of left lower third molar and subject gender. A logistic regression model was created using the statistically significant data.Results: The lower third molar impaction on the distance between mandibular retromolar foramen and mandibular angle was not significantly different between mean groups (absence and presence) when gender is disregard. The distance between the two was significantly increased in the male subgroup.Conclusion: The relation between the distance between mandibular retromolar foramen and mandibular angle and third molar using panoramic radiographs showed no fundamental difference in the distance between mandibular retromolar foramen and mandibular angle in case of absence or presence of lower third molar when gender is disregard.