A series of novel heterocyclic derivatives [A1-A7] have been synthesized by the alkylation reaction of the (SH, NH, OH) of various heterocyclic (oxadiazole, thiadiazole,4-hydroxy coumarin and benzothiazole) with chloro acetone or 2-bromoacetophenone. The resulting percentage yield of synthesized compound was relatively (69-85%). The producing compounds have been identified by infrared radiation (IR), proton nuclear magnetic resonance (1H-NMR), Carbon-13 nuclear magnetic resonance (13C-NMR) spectroscopy, and the quantities of various physical properties (melting point, crystal shape, and color). The synthesized derivatives were examined for their antioxidant activities.