The stem cells possess various possibilities in the regeneration of organs and tissues, thereby helping in the restoration of their normal function. Various types of stem cells and their characteristics such as source, function, limitations and their applications are discussed in detail in this article. Dental and Non-Dental Oral MSC (Mesenchymal Stem Cells) are being compared based on their proliferation ability and regenerative capacity. This article also depicts the regenerative applications of oral mesenchymal stem cells.