Moringa oleifera is a medium-sized tree that stands 10-12 metres tall. It is also known as the “Drumstick” tree, the horseradish tree, and the mother’s closest friend. The leaves of Moringa oleifera have an abundance of minerals like calcium, potassium, zinc, magnesium, iron, and copper. When pathogens enter the body via food, the condition is often called "food poisoning." Hydro-alcoholic extraction, simple distillation was subjected to powdered Moringa oleifera leaf. The extract was again heated using a water bath, and the crude drug was obtained. In vitro, anti-bacterial screening is performed by the disc diffusion method. Escherichia coli-Gram-negative bacteria were grown on nutrient agar in the refrigerator. Similarly, streptomycin was prepared as a standard antibacterial drug. The test drug and standard drug of streptomycin were compared for their zone of inhibition. Parameters such as organoleptic, microscopic, physical and chemical were evaluated. The presence of an alkaloid confirms the antibacterial activity. The 500 mg of orally disintegrating tablet was prepared by the direct compression method using a 10 mm diameter stainless steel die. Along with the crude drug powder, microcrystalline cellulose (MCC) was used as a diluent/binder and mannitol as a sweetener. The tablet was further evaluated.