Periodontal diseases have alarmed the current scenario globally. Still very less evidences has been clued in this area. Previously it was thought that virus is not involved with severe cases of periodontitis. In 20th century, virus association of periodontal cases has shown for the first time. After that several studies covered the strong evidences about direct virus isolation from deep focal sites. The articles published recently in journals of repute has shown a very strong evidences in the involvement of human herpes virus, Epstein Barr virus, Human cytomegalovirus, Human Immunodeficiency Virus in both chronic as well aggressive periodontitis. Our main aim of this review is to have compiled information in this article for what have been done in the area and remaining futuristic approach; as a current concern. This will not only help in early diagnostic and virus characterization as well identification of biomarkers for disease. The compiled information and critical aspects in the area will also help to develop suitable diagnostics and therapeutics.These uncertainties have given targeted efforts to find viral etiologic factors for periodontitis.