Background: Basic life support or BLS is an early emergency intervention cases which possibly happens anywhere. BLS is important to be given accurately and immediately not only by healthcare professionals but also by lay people in order to give early intervention towards emergency cases until medical teams arrives. ‘Aisyiyah cadre, as part of the society, are expected to be able to give early intervention that is BLS correctly.Objective: To assess the impact of basic life support training on the knowledge of ‘Aisyiyah cadre towards basic life support.Method: This study is a analytical observational study with cross-sectional approach. The sample of this study is 38 participants which are ‘Aisyiyah cadre from Malang city. Participants included on this study are those who do not have any medical background. Data analysis were using wilcoxon test.Result and discussion: 13 participants were having knowledge improvement, 24 participants did not have any improvements, and one of the participants were having degradation of knowledge level after the BLS training were given. According to wilcoxon test, the p-value was 0,001 which means that the BLS training given have positive impact on the improvement of ‘Aisyiyah cadre’s knowledge towards BLS.Conclusion: There is a significant impact between BLS training on the knowledge of ‘Aisyiyah cadre towards BLS which indicates that the BLS training given have postivive impact on the improvement of ‘Aisyiyah cadre’s knowledge towards BLS.

Penyakit Akibat Kerja (PAK) merupakan masalah kesehatan akibat kerja, khususnya pada perusahaan industri. Kasus PAK di dunia tercatat lebih dari 30% PAK merupakan penyakit paru. Penurunan faal paru dapat diakibatkan oleh beberapa faktor terutama pada pekerja industri. Faktor yang mempengaruhi penurunan faal paru diantaranya adalah lingkungan kerja dan karakteristik pekerja. Menganalisis lingkungan kerja dan karakteristik pekerja terhadap faal paru pekerja industri papan semen rata di PT “X” Malang. Observasional, Pendekatan Cross Sectional, Total Sampling. Hasil penelitian menunjukkan bahwa pekerja yang memiliki gangguan faal paru sebanyak 202 pekerja (71%), 68% diantaranya mengalami gangguan faal paru tipe restriktif dan 3% mengalami obstruktif. Faktor-faktor yang berpengaruh terhadap faal paru berdasarkan uji korelasi adalah status gizi, kebiasaan olahraga, kebiasaan merokok, penggunaan APD saat bekerja dan riwayat pekerjaan sebelumnya di bidang industri dengan p value < 0,05. Sehingga hasil analisis uji statistik yang telah dilakukan membuktikan adanya pengaruh yang signifikan antara lingkungan kerja dan karakteristik pekerja terhadap faal paru pekerja industri papan semen rata di PT “X” Malang. Status gizi, kebiasaan olahraga, kebiasaan merokok, penggunaan APD (masker) dan riwayat pekerjaan sebelumnya di bidang industri berpengaruh terhadap faal paru pekerja industri papan semen rata di PT “X” Malang. Kata Kunci: PAK, Gangguan Faal Paru, Pekerja Industri, Lingkungan Kerja, KarakteristikPekerja

In body composition, we can find out whether a person's nutritional status is obese or not. Where we know that obesity increases the risk of non-communicable diseases such as diabetes mellitus, cardiovascular disease, and cancer. One method that can help reduce the possibility of these problems is fasting. A method that one of the goals is to rest the body, especially the digestive system, and get rid of harmful toxins in the body. This study aims to determine the effect of Ramadan fasting on fat mass and body mass index in late adolescence. This research is an analytic observational research with Cross Sectional method. The sample in this study was a student of FK UMM who served as an assistant lecturer in the biomedical laboratory. The analytical test used is the Friedmen and Wilcoxon tests. The results obtained include: (1) The average BMI of respondents is 23.94 ± 4.3 and the majority are classified as having a normal BMI of 56.7%. While the average fat mass (%) was 28.56 ± 9.15 and the majority were in the obese category (50%). (2) there was an increase in BMI in week 2 of the Ramadan Fasting but only slightly, then at week 3 it was obtained an average that was almost the same as the first week of the Ramadan Fast. Friedman test results resulted in p value = 0.472. (3) Wilcoxon test to determine the effect of fasting in each week obtained a significance value of more than 0.05. (4) Friedman test results to determine the effect of Ramadan fasting on body fat mass, the p value = 0.145. In conclusion,Ramadan fasting has no effect on body fat mass and body mass index.

Acetaminophen is widely used as a fever and pain reliever drug. However, acetaminophen intoxication was common and responsible for thousands of acetaminophen-induced liver injury (AILI) cases worldwide. It was understood that glutathione (GSH) depletion causes a deposit of acetaminophen metabolites which are toxic to liver cells. N-acetylcysteine (NAC), used as acetaminophen intoxication therapy, has been reported to cause side effects such as nausea, vomiting, and anaphylactic reaction. This narrative review aimed to discuss other potential candidates in AILI management. The biomolecular approach was used to investigate onion skin in-depth and holistic discussion. According to the results, onion peel extract is rich in flavonoids (quercetin and kaempferol) and potentially be a candidate in the management of AILI through proposed mechanisms such as restoration of reduced glutathione (GSH), inhibition of cytochrome P450 (CYP) enzymes, upregulation of uridine 5'-diphospho-glucuronosyltransferase (UGT) enzyme, and inhibition of TLR4 activity.