The aim of this studies to know the relationship between gratitude, social support for the psychological well-being of persons with disabilities. Subjects in this study were persons with physical disabilities in Yogyakarta who were of productive years. The sampling technique in this study was purposive sampling with a subject of 56 people. The measurement of this study was done using questionnaire method. The results of data analysis was done using regression analysis technique of two predictors that there is a significant relationship between gratitude and social support for psychological wellbeing in persons with disabilities as indicated by R value of 0.415 and F regression of 17.764 with p <0.01. There is a significant positive relationship between gratitude and psychological well-being indicated by a significance value of 0.078 (p <0.05). Then a very significant positive relationship between social support and psychological wellbeing was indicated by a significance value of 0.708 (p> 0.05).