Neurogenic bradycardia which can lead to cardiac arrest is a rare, but well-recognized complication of anesthesia. we report the cases of two patients admitted for craniotomy who presented intraoperative bradycardia due to TrigeminoCardiac Reflex and Hypothalamic stimulation immediately reversible after cessation of stimulation. The importance of having the knowledge, vigilance, equipment and skills to quickly deal with such a case will be critical to the survival of the patient.