Introduction. Occupational injuries are occurrences arising out of, or in the course of, work which results in a fatal or nonfatal injury, e.g., a fall from a height or contact with moving machines. They pose psychological, behavioral, social, vocational, and economic problems. No previous studies have been conducted on the prevalence and associated risk factors of occupational injuries among workers in Bahir Dar Textile Share Company (SC). Therefore, this study aimed to assess the prevalence and associated risk factors of occupational injury in Bahir Dar Textile SC, Northwest Ethiopia. Methods. A cross-sectional study was conducted among employees of Bahir Dar Textile SC in 2019. Three hundred (195 males and 105 females) employees were selected using proportional simple random sampling from the spinning, weaving, finishing, engineering, and administration sections. Results. The one-year and the two-week occupational injury prevalences were 42.7% and 6.7%, respectively. The one-year report from all the respondents shows that abrasion (10.7%) and eye injury (7.7%) were the two top injuries, hands (12.7%) and eyes (7.7%) were the top injured body parts, and machines (22.7%) and falling/slipping (6.3%) caused most injuries. Statistically significant differences in injuries (p<0.05) were observed due to variations in gender, job category, exposure to vibration, exposure to rays/welding sparks, and labor-intensive work. The weaving section was positively associated with occupational injuries at AOR = 4.497 and p=0.05. Conclusions. Occupational injuries prevalence is high over the last year. The major causes of injuries were machines and falling/slipping, while the major injuries were abrasions, eye injuries, sprains, and burns. The factors significantly associated with occupational injuries were male gender, job category, use of vibrating tools, high intensive work, and rays/welding sparks. Occupational safety and health training, use of personal protective equipment (PPE), and shifting employees from intensive works are recommended.