Melasma is a very common disorder of hypermelanosis affecting face. The pigmented patches usually affect darker complexioned individual especially Asian. An interventional study was carried out to detect the efficacy and safety of triple combination agent (4% Hydroquinone, 0.05% Tretinoin and 0.05% Clobetasone butyrate) in the treatment of melasma. Total 50 clinically diagnosed cases of melasma attending in outpatient department of Dermatology and Venereology, Diabetic Association Medical College Hospital (DAMCH), Faridpur were evaluated. Maximum patients (40%) were between 31-35 years of age and 80% were female. Sun exposure (60%) and contraceptive pill (36%) were common precipitating factors. Of them 54% patients have skin type IV, 24% patients have skin type III. Centrofacial melasma (64%) was the commonest pattern of melasma. MASI score at base line was 9.45, and after 12th week were 4.62. After completion of therapy there was remarkable reduction (51.11%) of severity of melasma. The triple combination agent were well tolerated and commonly observed side effects were erythema (34%) and burning (22%). This study demonstrates that every night application of triple combination agents has significant lightening effect in the treatment of melasma.a DOI: http://dx.doi.org/10.3329/fmcj.v8i1.16893 Faridpur Med. Coll. J. 2013;8(1): 22-25

:Scabies is one of the commonest diseases among all age groups. Topical permethrin is a widely used treatment option for scabies. Ivermectin is a newer oral agent for the treatment of scabies. This study was done to compare the efficacy of permithrin and oral Ivermectin in the treatment of Scabies in patient suffering from Diabetes mellitus. This comparative clinical trial was carried out in the outpatient department of Dermatology & Venereology, Diabetic Association Medical College Hospital (DAMCH), Faridpur from January 2012 to December 2012. A total 60 cases were enrolled purposively and divided into 2 groups. Group I received 2 doses oral Ivermectin and group II treated with 5% permethirn cream. Patients were followed up at the 3rd and 4th week. Total 86.6% patients of Ivermectin group and 90% of permethrin group were cured. Though permethrin showed somewhat more effective, the difference was not statistically significant. The study found that both ivermectin and permethrin were similarly effective in the treatment of scabies in patients suffering from Diabetes Mellitus.

J Bangladesh Coll Phys Surg 2012; 30: 211-218 DOI: http://dx.doi.org/10.3329/jbcps.v30i4.14764