Background Intracranial hemorrhage is the third most frequent cause of cerebrovascular disease, also known as cerebral bleed, intraparenchymal bleed and hemorrhagic stroke. This study was designed to detect the possible present of factor II   polymorphism (G20210A) among Sudanese patients with Intercereberal hemorrhage. Material and method This study was cross sectional hospital-based study,conducted at the research laboratory of the national center of neurological sciences (NCNS), Khartoum, Sudan during the period June 2022 to August 2022.It included all patients attended with intracerebral hemorrhage, demographic data ( age , gender, associated disease ). DNA extraction was done from blood of all patients and control.PCR for factor prothrombin gene was done and thus Sanger sequencing. Results: The PCR results showed; 100% positive forfactor II gene. And sequencing result showed base bare exchange in factor II gene G to A (G20210A)polymorphism . Conclusion Factor II gene polymorphism (G20210A) was detected and might be association with Intercereberal hemorrhage among Sudanese patients

Background Intracranial hemorrhage refers to any bleeding within the intracranial vault, including the brain parenchyma and surrounding meningeal spaces. In Sudan, there is no published data regarding factor V Leiden mutation. Therefore this study was designed to detect the possible present of factor V polymorphism (G1691A) among Sudanese patients with intercereberal hemorrhage. Material and method This study was a cross sectional hospital-based study, conducted at the research laboratory of the national center of neurological sciences (NCNS), Khartoum, Sudan during the period June 2022 to August 2022.It included all patients attended with Intracerebral hemorrhage, DNA extraction was done from blood of all patients and controls.PCR for factor V gene was done and thus Sanger sequencing. Results The PCR results showed; 100% were positive for factor V gene. Sequencing results revealed single based exchange in factor V geneG to A (G1691A). Conclusion Factor V gene polymorphism (G1691A) was detected and might be in association with intercereberal hemorrhage among Sudanese patients

Background: Intracerebral hemorrhage (ICH) is a sudden bleeding into the tissues of the brain, into its ventricles, or into both. It is the second most common subtype of stroke and is a critical disease usually leading to severe disability or death. Material and method: This study was a cross sectional hospital-based study, conducted at the research laboratory of the national center of neurological sciences (NCNS), Khartoum, Sudan during the period June 2022 to August 2022.It included all patients attended with intracerebral hemorrhage. DNA extraction was done from blood of all patients and control. PCR for factor XIII gene was carried out and thus Sanger sequencing to both cases and controls. Results: The PCR results showed; 100% samples were positive for factor XIII gene.Sequencing result showed the detection of threepolymorphisms in factor XIII gene (G>T, A>G and C>T) . Conclusion: The detected factor XIII gene polymorphisms (G>T, A>G and C>T) might be associated with intercereberal hemorrhage among Sudanese patients. Keywords: Factor XIII, gene, polymorphism, hemorrhage, stroke, cerebrovascular