This paper uses a new survey data set on manufacturing firms in Cameroon to estimate a Cobb-Douglas production function. Based on a categorization of firms by ownership structure and firms aiming at analysing the constraints surrounding the use of Information and Communication Technologies (ICT) as a tool to improving productivity of Small and Medium-sized Enterprises (SME) in Cameroon, we have evaluated empirically whether to what extent those technologies have contributed to the growth of labour productivity within the firms. Using the Instrumental Variables method, to account for the endogeneity problem with cross sectional data, we found a positive and significant impact of ICT-capital on labour productivity in Cameroonian's firms.