: Recent years have witnessed a rapid development of environmentally sustainable organic processes that can stop eventual depletion of our eco-system with wider implications on the day-to-day practice in academic laboratories and industries. Use of biocompatible raw materials as catalyst, solvent, and synthetic precursors; continuous attempt to design ideal synthetic processes; and use of energy-efficient strategy such as multicomponent reactions have potential to achieve sustainable organic synthesis. In this review, it is aimed to discuss the applications of nature’s chiral pool such as amino acids, carbohydrates, and their readily accessible derivatives as catalyst, solvent and raw materials for synthesis of diverse molecular targets.

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