The study examined the assessment of the cost-benefits of climate change adaptation strategies of cassava-based farmers in Southern Nigeria. About 300 cassava-based farmers were selected using simple random sampling. Primary data were obtained through administration of questionnaire, interview schedule and Focus Group Discussion (FGD). Data were analyzed using descriptive and inferential statistics, Net Return model and Cost-Benefit Analysis (CBA). The findings of this study revealed that more than 55% of the cassava crop farmers indicated depletion of the ozone layer as the most cause of climate change in the area. The net returns of the cassava production were estimated at ₦215,240.86 ($614.97) and the gross marginal returns of ₦220,078.86 ($628.80) respectively. This indicates that cassava production using the adaptation strategies is profitable. Conservational agriculture recorded the highest internal rate of return of 68% over other adaptation strategies with Net Present Value of E399.53. The factor analysis revealed the major constraints in using climate change adaptation strategies as high cost of labor, inadequate information on climate change issues, high cost and scarcity of inputs, insecurity, poor extension services and low response from government among others. Farmers should be encouraged to practice conservation techniques as the cost-effective and efficient climate change adaptation strategies in the study area. Government support in bridging the gap between climate change and crop farmers’ adaptation strategies and farm inputs provisions at a subsidized rate were recommended.