Psychopharmacological disorders are among the leading cause of non-fatal disease burden in India. One in seven Indians was affected by psychopharmacological disorders. Although psychopharmacological agents is used for the management of psychological disorders like anxiety, psychosis, depression and mania it may side effects such as tardative dyskinesia, weight gain, weight loss, muscle cramps, dysphoria, gastrointestinal upset, eye problems or problems with blood tests. In this present review we made an exposure regarding many screening methods on evaluation of psychopharmacological disorders like anxiety, depression, psychosis and mania in the aspects of preclinical studies. These methods are very useful to evaluate the psychopharmacological agents like anti-anxiety agents, anti-psychotics, anti-depressants and anti-manic agents.

Syzygium cumini (L.) Skeels, commonly known as Jamun, is a widely distributed forest tree in India and other tropical and sub tropical regions of the world. The tree has a great economic importance since most of the parts like the bark, leaves, seed and fruits are used as an alternative medicine to treat various diseases. The present study aimed at the in-vitro anthelmintic activity of aqueous fruit seed extract of Syzygium cumini. The fruit seeds were extracted separately with distilled water by maceration method .The various concentrations of the extract (50,100, 200,300,400mg/ml) respectively were screened for their anthelmintic activity using Pheritima posthuma. The activity was comparable with the standard drug albendazole. When the concentrations of the extract are increased, a gradual increase in anthelmintic activity is observed. The study involved the determination of time of paralysis (P) and time of death (D) of the worms. Aqueous fruit seed extract of Syzygium cumini showed anthelmintic activity against Indian earthworms. The data were found statistically significant by using one way ANOVA (P< 0.001).