Background: Cholelithiasis is a condition in which rare in children but in recent years has been increasing due to ultrasound used. This problem associated to inflammation, infection, obesity, children who received long total parenteral nutrition, resection of bowel, chronic liver disease or genetic. Most of cholelithiasis in children are asymptomatic. Gallstones are divided into cholesterol stones and pigment stones, could be on lucent or opaque description in abdominal x-ray. There are no special guidelines defined indications for medical or surgical treatment in children with cholelithiasis. Case Presentation: A 7 years 2 months old boy complaint of abdominal pain getting worse since 6 hours before admission; colicky pain, does not spread to other region of abdominal, and especially after eating. Vomit was frequently after eating. Symptoms are repeated for 3 times hospitalization and established as acute pancreatitis in second hospitalization but confirmed as cholelithiasis in recent admission. Conclusion: cholelithiasis in children could be related to inflammation and/ or infection of organs around the gallbladder. Keywords: Cholelithiasis, acute pancreatitis, chronic cholecystitis, case report.