Objective: The aim of this study was to formulate the floating gastroretentive of amoxicillin using hard alginate capsules shell and evaluate the antibacterial activities of floating gastroretentive of amoxicillin.Methods: Amoxicillin was prepared in the solid dispersion form, it was prepared by a solvent method using polyvinylpyrrolidone (PVP) K30.The solid dispersion was characterized by X-ray diffraction and Fourier transformed infra-red analysis. The drug was filled into alginate capsule shell. Drug release test was carried out using USP paddle method in simulated gastric fluid. Concentrations of amoxicillin were determined using spectrophotometer ultraviolet at wavelength of 272 nm. The antibacterial activity of aliquots dissolution was assessed using agar plate diffusion method against Staphylococcus aureus and Escherichia coli as bacterial model. Results:The dissolution test results showed that amoxicillin in the solid dispersions form with a weight ratio of amoxicillin and PVP K30 was 1:1 caused sustained release of amoxicillin for 12 hrs, while the release of amoxicillin without solid dispersion was too slow. The floating lag time was 0 minute and floating time was more than 12 hrs. The X-ray diffraction pattern of amoxicillin solid dispersion had amorphous shape. Antibacterial activity test showed that the dissolution aliquots of amoxicillin solid dispersion were effective against S. aureus and E. coli. Conclusions:Based on the results of this study, it is concluded that the alginate capsules shell can be used for the preparation of floating gastroretentive of amoxicillin using amoxicillin solid dispersion and the dissolution aliquots give antibacterial effect.

No abstract