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Derivatives of 2-aminothiophene-3-carbonitrile, 2-thioxopyridine-3-carbonitrile, 1,8-naphthyridine-2one, thieno[2,3-b]pyridine-5-carbonitrile and thieno[2,3-d]pyrimidine incorporating with a 1H-b e n z otriazole moiety or 1,3,4-thiadiazole derivatives incorporating with a benzotriazol-1-ylmethyl group have been synthesized and tested for antimicrobial and antifungal activities. The structures of the newly synthesized compounds have been established on the basis of their analytical and spectral data. Pharmacological studies of the 1H-b e n z o t r i a z o l e nucleus have been shown to posses a variety of pharmacological activities such as anti-inflammatory [1], antimicrobial [2-4], anticonvulsant and CNS depressant [5] effects. Furthermore, several pharmacological studies have also pointed out the value of 2-aminothiophene [6,7], naphthyridine [8], thieno[2,3-d]pyrimidine [9,10], thieno[2,3b]pyridine [11] and thiadiazole [12] as biologically active nuclei. These findings focused on incorporating 2aminothiophene-3-carbonitrile, 2-thioxopyridine-3-carbonitrile, 4-amino-2-oxo-1,8-naphthyridine-3-carbonitrile, 4 -a m i n o t h i e n o [ 2 , 3 -b]pyridine-5-carbonitrile and thieno[2,3-d] pyrimidine with 1H

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The utility of both 3‐(1‐benzotriazolyl) chalcone derivatives 3a‐c and 2‐(1‐benzotriazolyl)‐1,4‐pentadien‐3‐one (18) in the synthesis of some new 2‐(1H)‐pyridone, pyridine, pyrazole and isoxazole derivatives is reported. Antimicrobial and antifungal screening of some selected examples from the synthesized products were carried out. The structure of the newly synthesized compounds was elucidated by elemental analysis, ir, 1H and 13C nmr investigations.

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