Background: Maternal mortality, a great tragedy of our time, occupies a large armamentarium in the world reproductive health burden picture and has remained a recurring problem in the global family health. Objective: To review the strategies towards reducing maternal mortality in a low resource setting; using South Sudan as a case study Methodology: Electronic search of published articles on maternal mortality and maternal mortality-related issues, published between 1992 and 2022, was conducted through PubMed, Cochrane libraries, Google search engine and semantic scholar. This was complemented with advanced search using Boolean operators to make the search more focused. The search was however restricted to only articles written in the English language. Conclusion: South Sudan needs a selfless leadership structure in order to achieve the necessary will for the actualization of the outlined sociocultural, economic and medical strategies to combat the country's exceptionally high maternal mortality ratio.