This study aims to determine the effect of the use of information technology on employee performance, which is mediated by user satisfaction and the suitability of technology tasks. Respondents in this study were employees of PT Kimia Farma Pharmacy Yogyakarta Business Unit. The sample used was 110 respondents, with a quantitative method using SEM and AMOS. From the data that has been tested and collected, the results of this study indicate that the use of information technology has a significant positive effect on employee performance and task-technology fit. User satisfaction and task-technology fit do not mediate the positive and insignificant effects of using information technology on employee performance. User satisfaction has no positive effect on performance and is insignificant. Task-technology fit has a positive effect on performance.