An ethnobotanical survey was conducted to record the various plant families, species, and plant parts used to manage sickle cell disease in the Indenié-Djouablin region eastern Côte d’Ivoire. Nine traditional healers aged 36 to 67 years old were selected in six different villages according to their reputation in knowledge of traditional medicine, their availability and their willingness to share information. A total of 26 species of plants belonging to 20 families were reported to have antisickling activity. Eleven (11) different medication recipes were composed from these 26 species of plants ((Afromonum melegueta (Roscoe) K. Schum., Xylopia aethiopica) mainly). The main plant parts used were stem bark (38%) followed by fruit (18%) and seeds (18%). The majority of the main plants recorded (84.61 %) were wild. From the recorded plants, 65.38 % were trees and 23.07 % shrubs. Most remedies (82%) were made up by decoction and were employed orally (54 %) or by enema (32 %). The potential anti-sickling activity of the plant species recorded during this study could be the effect of alkaloids, polyphenols, quinones and terpenoids compounds found during the phytochemical screening of the 26 plants species.

http://indexmedicus.afro.who.int Évaluation de l'activité antibactérienne des extraits de fruits de Solanum torvum Swartz (Solanaceae) sur la croissance in vitro de sept (07) souches d'entérobactéries de différents profils (résistantes ou sensibles)

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Dans le but d'apporter notre contribution à la lutte contre les candidoses opportunistes, nous avons testé dix-sept fractions chromatographiques d'un extrait hexanique de Mitracarpus scaber codifié Misca sur la croissance in vitro de Candida albicans et Candida glabrata. Les tests antifongiques ont été réalisés sur milieu Sabouraud auquel l'extrait végétal a été incorporé selon la méthode de la double dilution en tubes penchés. Les concentrations varient de 3 125 à 12 µg/ml. Les résultats ont montré que dans cet intervalle de valeurs, seules les fractions F 6 , F 7 , F 8 ont permis une nette inhibition de la croissance des deux souches de Candida à 781 µg/ml. Parmi elles, la fraction F 8 possède la meilleure activité anticandidosique avec une CI 50 = 16 µg/ml sur Candida albicans contre CI 50 = 45 µg/ml sur Candida tropicalis qui est donc la souche la moins sensible. La fraction F 8 de l'extrait hexanique est donc celle qui concentre le mieux les principes actifs anticandidosiques de Misca. Mots clés : Misca -Activité anticandidosique -Fractionnement chromatographique Improvement by chromatographic dividing of anticandidosic activity of an hexanic extract Mitracarpus scaber on the in vitro growth of Candida albicans and Candida tropicalisAbstract: In the goal to bring our contribution to the struggle against opportunistic candidosis, we tested seventeen chromatographic fraction gotten from an hexanic extract of a Mitracarpus scaber Misca codified on the in vitro growth of Candida albicans and Candida tropicalis. Antifungal tests have been made on Sabouraud medium culture. Extract has been inserted to this medium according to the Agar slant method. The range of concentrations has been fixed between 3.125 µg/ml and 12 µg/ml. Results showed that in this interval of values, alone fractions F 6 , F 7 , F 8 permitted a clean inhibition to 3 125 µg/ml of the growth of the 2 strains of Candida. Among them, the fraction F 8 has possessed a better anticandidosic activity with IC 50 = 16 µg/ml on Candida albicans against IC 50 = 45 µg/mls on Candida tropicalis which is the least sensible. So, the chromatographic fraction F 8 obtained from a hexanic extract is the one that permits a better concentration of active principles of Misca.

Background: Herbal medicinal preparations are used as dietary supplements for disease prevention and as alternative/complementary medicine. The growing interest in herbal medicine raises the question of its safety and efficacy. Numerous recorded cases of intoxication and toxicological studies reveal that medicinal plants can be toxic, which hinders their safe use. Plant intoxications related to a variety of factors include plant organs and many extraction solvents. Little toxicological data on medicinal plants is available. The need to investigate is important for safe use. Imperata cylindrica, a poaceae, is one of the medicinal plants for which few toxicological data are available. Materials