Background: Skin aging is a condition where skin is unable to retain both its physiological and structural integrity. Plants is the main source of phtytochemicals compound with wide range of biological activities. Through the efforts of ongoing scientific researches, an increasing number of plant extracts and phytochemicals have been showed promising result as anti-aging agent. Snake fruit (Salacca zalacca (Gaert.) Voss) is tropical plant belongs to the palm tree family (Arecaceae) that served as important crop in Indonesia. Despite its utilization, the phytochemical compound available in snake fruit, especially its peel have not been well documented. Present study aimed to elucidate the phytochemical constituent of snake fruit peel and its anti-aging potency.Materials and Methods: Snake fruit peel extract (SPE) was subjected to qualitative phytochemical assay, high performance liquid chromatography, and molecular docking towards protein related in skin aging.Results: The screening showed SPE contained phytochemical compound belong to flavonoid, tannin, phenol, triterpenoid, saponin and alkaloid. Thus, based on the analysis only chlorogenic acid was present in SPE whilst rutin and caffeic acid were not detected. The SPE was contained chlorogenic acid around 1.074 mg/g dry weight. Chlorogenic acid had the high binding affinity towards matrix metalloproteinase (MMP)-1 (-9.4 kcal/mol).Conclusion: Current findings may provide scientific evidence for possible usage of SPE and its compounds as antioxidant and anti-aging agent.Keywords: Salacca zalacca, phytochemical compound, high performance liquid chromatography, anti-aging

Objective: The purpose of the study was to investigate the acceleration of the wound healing properties from lemon pepper’s essential oil as the lemon pepper’s ointment. Methods: There were 20 Wistar rats as an animal trial divided into four sample groups, including control (ointment base), standard (Nebacetin®), 5% lemon pepper, and 10% lemon pepper ointment, and all groups were injured by electric soldier for 10 s. The wound contraction and epithelialization period were the parameters of wound healing activity. Result: Wound contraction as the parameter of wound healing showed significant difference between the standard and lemon pepper ointment (p<0.05). The lemon pepper ointment groups showed no significant wound contraction difference in each lemon pepper ointment concentration at the initial time of observation, however, it become more obvious at last period of observation. Furthermore, the epithelialization period did not showed any significant differences between standard, 5% or 10% lemon pepper ointment against the control group (p>0.05). Conclusion: It can be concluded that the lemon pepper ointment had the potential to accelerate wound healing activity.

Background: Workload and quality of peer care has an important role in improving the quality of medical services in terms of patient satisfaction in hospital services, especially in the inpatient room. RSU. Royal Prima is a private type B hospital with a BOR of 87% based on the high number of patient visits in the inpatient room. The aim of the study was to determine the analysis of the influence of the workload and the quality of medical services in the inpatient building B RSU, Royal Prima Medan 2019.Methods: This type of quantitative research with a correlation study research design. On the workload of nurses with a total sampling technique of 148 nurses. On the quality of nurses using a purposive sampling technique, a sample of 148 people was taken from one month's patient population.Results: The results of this study on nurse workload from the measurement results based on the chi square test nurses workload has a statistically significant effect on the quality of medical services (p=0.005) and the quality of nurses has no influence on the quality of being able (p=0.950). Based on logistic regression odds ratio 1.025, which means nurses with light workloads will improve the quality of service 1.0 times compared to nurses with heavy workloads.Conclusions: It was concluded that the heavy workload can affect the quality of inpatient services marked by the number of patients not proportional to the number of nurses so it is necessary to increase the number of nursing human resources in the inpatient room of B building at RS, Royal Prima Medan in 2019.

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Diare masih menjadi masalah utama kematian kedua pada anak dibawah usia lima tahun data World HealthOrganization (WHO) menyatakan hampir 1,7 miliar kasus diare yang terjadi pada anak, Makanan dan minumanyang terkontaminasi oleh mikroorganisme menjadi faktor risiko penyebab diare, termasuk bakteri Shigelladysenteriae. Ekstrak kulit manggis (Garcinia mangostana L) mengandung banyak senyawa kimiawi terutamaxanthone yang memiliki daya antibakteri dan buah pare (Momordica charantia L) mengandung senyawa kimiasaponin dan alkaloid memiliki aktivitas sebagai antibakteri. Penelitian ini dilakukan untuk mengetahuiperbandingan efektivitas ekstrak kulit manggis (Garcinia mangostana L) dan buah pare (Momordica charantiaL) sebagai antidiare terhadap pertumbuhan bakteri Shigella dysenteriae. Ekstrak kulit manggis dan buah parediekstraksi dengan metode maserasi menggunakan pelarut etanol 96%, selanjutnya kedua ekstrak dibagidengan konsentrasi 25%, 50% dan 75% untuk kontrol positif menggunakan antibiotik chloramphenicol dancontrol negative menggunakan aquadest. Pada penelitian ini diperoleh dari hasil uji statistik independent t testbahwa p value = 0,553 (p>0,05) yang berarti tidak ada perbedaan yang signifikan antara ekstrak kulit manggis(Garcinia mangostana L) dan buah pare (Momordica charantia L) dalam menghambat pertumbuhan bakteriShigella dysenteriae. Dari hasil ini dapat dinyatakan bahwa ekstrak kulit manggis dan buah pare sama-samakuat dalam menghambat bakteri Shigella dysenteriae.Kata Kunci : kulit manggis (Garcinia mangostana L), buah pare (Momordica charantia L), Shigella dysenteriae