Providing parenteral nutrition at home has significant challenges for both patients and providers alike. Some of these challenges are systemic and are secondary to the way the healthcare system is designed to deliver care. Others are more practical and require educating patients and their families to ensure success at home. Overall, the nutrition support team was designed to help deal with these challenges in an effective way. The changing realities of the modern health system are challenging the nutrition support team to adapt to new obstacles. Providing patients with the tools to succeed at home requires a significant amount of time and investment but will pay dividends in the future as patients thrive for years to come.