Using modern NMR techniques, including 1H--13C and 1H--15N heteronuclear correlation experiments, the complete and unambiguous 1H, 13C, and 15N NMR chemical shift assignments of annomontine, methoxyannomontine, and N-hydroxyannomontine pyrimidine-beta-carboline alkaloids were performed. All 1H--1H scalar coupling constants and signal multiplicities were determined, and all nOe observations were also included.
In the course of our studies on the nucleophilicity of the 5-position of substituted pyrimidines we obtained 4,6-dihydroxypyrimidine-5-carbaldehyde (2) by reaction in chloroform a t 0 to 20 "C of 4,6-dihydroxypyrimidine (prepared from malondiamide and formamide) with the reaction product of dirnethylformamide and phosgene 121. The formylation was exothermic with a yield of 93 % after 2 to 3 hr.Chlorination of the quaternary salt ( I ) with phosphorus oxychloride/dimethylaniline, or of ( I ) in dimethylformamide with phosgene/dimethylaniline (10 hr at 110 "C) and subsequent removal of the solvent, treatment of the residue with ice, and extraction with chloroform afforded 4,6-dichloropyrimidine-5-carbaldehyde (3) in 63 % yield [1,31.The formylation and chlorination can be carried out in one experiment : after the reaction with the dimethylformamidephosgene product the chloroform is removed and replaced by dimethylformamide, and phosgene is passed into the mixture for 10 hr at 110 "C. Hydrogenation of the chloro-aldehyde (3) with hydrogen and palladium-charcoal in methanol containing an excess of magnesium oxide (to remove the HCI) at room temperature and pressure and subsequent filtration, distillation of the methanol, and extraction of the residue with methylene chloride yielded the new compound pyrimidine-5-carbaldehyde, rn.p. 38-41 "C, in 79 % yield (40 % calculated on rnalondiamide).(2) H 1 NJ.C-CHO
Introdução: O ambiente de trabalho é um campo de estudo amplo. Atividades laborais informais, principalmente nos centros urbanos, como o mototaxismo, torna-se um campo de estudo devido às dificuldades para a melhoria do ambiente de trabalho atrelado aos desafios para a saúde. Objetivo: elucidar os panoramas sobre a capacidade de trabalho, qualidade de vida e saúde dos trabalhadores mototaxistas. Metodologia: revisão integrativa de literatura feita nas bases de dados Biblioteca Virtual de Saúde (BVS) e Scientific Electronic Library Online (SCIELO). Resultado e Discussão: Após a leitura na íntegra dos artigos selecionados tornaram-se elegíveis 22 artigos científicos que responderam ao objetivo da pesquisa, no total de 12 da base SCIELO e 10 BVS; O compilado de pesquisa retrata a realidade do mototaxismo traçando as condições sociais e ambientais em que executam suas atividades e as negativas consequências sofridas diminuindo a capacidade de trabalho e, consequentemente, sua qualidade de vida. Conclusão: A relação entre o trabalhador urbano mototaxista e saúde é evidente nos achados desta pesquisa, a mera exposição a ambientes poluentes acarreta em prejuízos abstratos e concretos que em decorrência da atividade podem não ser impedidos.
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