Mortality in acromegaly is normalized with biochemical control and decreased in the last decade with the more frequent use of SAs as adjuvant therapy. Increased life expectancy has been associated with more deaths due to cancer.

Key Points Question What is the interrater reliability of medical treatment orders documented in the Physician Orders for Life-Sustaining Treatment form? Findings In this cross-sectional study of interviews with 64 patients and decision-making surrogates in Brazil, the κ statistics for cardiopulmonary resuscitation, level of medical intervention, and artificially administered nutrition were high. However, disagreement in at least 1 order for life-sustaining treatment was found in 5 cases. Meaning The findings support the Physician Orders for Life-Sustaining Treatment paradigm as a means to translate patients’ values and preferences of care at the end of life into medical orders and stress the importance of frequently reviewing the content of the Physician Orders for Life-Sustaining Treatment form to ensure it reflects current preferences.

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