Quinoxaline, quinazoline and benzimidazole based templates have been synthesized on solid-support employing different methodologies. This review enlightens academic and industrial examples of combinatorial synthesis for this type of heterocycles that appeared in the literature in the last decade. Hence, some of the important synthetic strategies for the generation of quinoxaline, quinazoline and benzimidazole based privileged structures, and the important biological activities for these heterocycles have been highlighted. Further, benzothiadiazinone, thioxoquinazolinone, cinnoline and indazole are also examined in this review.

Synthesis and Anticancer Potential of Benzothiazole Linked Phenylpyridopyrimidinones and Their Diones as Mitochondrial Apoptotic Inducers. -Among the new compounds (III) and related diones (V), compound (IIIb) shows significant cytotoxicity against human cervical cancer cell line ME-180. DNA fragmentation and Hoechst staining reveals that this compound induces cell death by apoptosis. -(KAMAL*, A.; ASHRAF, M.; VARDHAN, M. V. P. S. V.; FAAZIL, S.; NAYAK, V. L.; Bioorg. Med. Chem. Lett. 24 (2014) 1, 147-151, http://dx.

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