Patient safety culture is viewed as an important organizational aspect that influences patient safety and is related to teamwork and communication about errors. The main aim of this paper is to highlight the perception of healthcare providers about patient safety within the current literature. Different databases were used for the search strategy and systematic literature search. Quantitative studies that have been eligible are those that have been conducted in clinical practice settings and other community settings. Key words for the search included healthcare providers, professionals, perception, safety, patient safety, safety climate, safety culture, patient safety culture, and Saudi Arabia. In several aspects of patient safety, such as the atmosphere of cooperation, healthcare providers had favorable attitudes. However, they also had more pessimistic views on other aspects, such as the assistance provided by management and the overall safety atmosphere. Policymakers, healthcare management, and doctors who want to build a culture of learning should prioritize educating future healthcare practitioners about patient safety and encouraging them to have direct and active engagement in patient safety processes. This will ensure that patients get therapy that is devoid of risks.