Cerebral Venous Sinus Thrombosis (CVST) is a cerebrovascular disease in the form of occlusion due to thrombus in the venous and cerebral sinuses which rarely occurs with varied clinical symptoms and radiological features and very difficult to diagnose. D-Dimer can be used as a diagnostic marker for cases of venous thromboembolism, with sensitivity of around 90-92%, but the specificity is not too high (70-73%) because it can also increase in other condition. Digital Subtraction Angiography (DSA) is a gold standard examination to establish the diagnosis of CVST. The purpose of this study was to determine the relationship between D-Dimer level and CVST using DSA at Dr Hasan Sadikin Hospital in Bandung. This study used an observational analytic method with case-control study design using retrospective data from medical records at Dr Hasan Sadikin Hospital from January 2017- August 2019. The research subjects were divided into 2 groups, namely the high D-Dimer levels and the normal/low D-dimer levels. There are 40 people who meet the inclusion criteria, ages averaging from 44.77±14.399 years and consists of 9 male patients (22.5%) and 31 women patients (77.5%). For normal/low D-Dimer levels 20 patients (50.0%) and high D-Dimer levels 20 patients (50.0%). Statistical test results measuring D-Dimer and CVST levels found a significant relationship (p <0.05). In conclusion, there is a relationship between D-dimer levels with CVST events that have been done by DSA. The higher the D-dimer level, the higher the suspicion of CVST.