Five new organotin(IV) complexes of <i>ortho</i>-vanillin-2-hydrazinopyridine hydrazone with formula [R<sub>n</sub>SnCl<sub>4–n</sub>(VHP)] [R = Me<sub>2</sub>, n = 2 (2); R = Ph<sub>2</sub>, n = 2 (3); R= <i>n</i>Bu<sub>2</sub>, n = 2 (4); R = <i>n</i>Bu, n = 2 (5) and R = 1, n = 0 (6)] have been synthesized by direct reaction of ortho-vanillin-2-hydrazinopyridine hydrazone [(VHP), (1)], base and organotin(IV) chloride(s) in absolute methanol. The hydrazone ligand [(VHP), (1)] and its organotin(IV) complexes (2-6) have been characterized by UV-Visible, FT-IR and <sup>1</sup>H NMR spectral studies. Spectroscopic data suggested that in the complexes (2-4), the ligand (1) acted as a neutral bidentate ligand and is coordinated to the tin(IV) atom <i>via</i> the azomethine nitrogen and pyridyl nitrogen atoms, whereas the ligand (1) acted as a uninegative tridentate ligand and coordinated to the tin(IV) atom through phenolic-O, azomethine-N and pyridyl-N atoms in complexes (5-6). The toxicity of the ligand (1) and its organotin (IV) complexes (2-6) were determined against <i>Artemia salina</i>. Organotin(IV) complexes showed moderate activity against <i>Artemia salina</i>. The ligand (1) and its organotin(IV) complexes (2-6) were also tested against four types of bacteria namely <i>Bacillus cereus</i>, <i>Staphylococcus aureus</i>, <i>Escherichia coli</i> and <i>Enterobacter aerogenes</i>. All organotin(IV) complexes and the free ligand (1) showed better antibacterial activities against bacteria. Among the organotin(IV) complexes (2-6), diphenyltin(IV) complex (3) showed higher activity against the four types of bacteria
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.