The present study in mice concerned about the immunized mice by Hydatid cystic fluid (HCFAgs) and treated with three anthelmintic drugs alone Albendazole (ABZ), Oxfendazole (OFZ) and Praziquental (PZQ) or in combined ABZ+ PZQ, OFZ + ABZ and OFZ+PZQ. Treatment with OFZ shows 93.75% efficacy, but it's more effective in combination with PZQ (96.7%), but it lower in combination with ABZ 82.5% or ABZ combined with PZQ 77.5%.The sera of the mice were screened for the biochemical enzymes. Liver and spleen were processed and paraffin embedded tissue sections were examined by immunohistochemistry (IHC) for IFN-gamma from different study groups. After treatment, liver and spleen express an increased IFN-ɣ protein in treated groups and positive control group compared with control negative group. We have evaluated of the pathological changes in liver and spleen of mice after four months of the infection and treatment. The result showed satisfactory histopathological changes in comparison with positive control group.