Jerawat (Acne vulgaris) adalah kondisi peradangan pada folikel sebaceous yang dapat menyerang pria dan wanita pada segala usia. Jerawat dapat disebabkan oleh berbagai keadaan, dan infeksi bakteri Propionibacterium acnes adalah salah satu penyebabnya. Propionibacterium acnes termasuk mikroflora yang terdapat pada kulit manusia, namun jika jumlahnya berlebih maka dapat menyebabkan jerawat. Pengobatan jerawat yang umum dilakukan adalah dengan menggunakan antibiotik atau berbagai produk sintetik/kimia yang beredar di pasaran. Penggunaan obat jerawat sintetik dapat menyebabkan terjadinya resistensi, iritasi, kerusakan organ, hingga hipersensitivitas imun. Oleh karena itu peneliti melakukan penelitian pemanfaatan bahan alam yaitu ekstrak herba Suruhan (Peperomia pellucida L. Kunth) sebagai alternatif bahan alam yang diformulasi dalam bentuk sediaan gel untuk mengatasi masalah jerawat. Gel dengan konsentrasi ekstrak 25% memiliki aktivitas antibakteri terbaik. Hasil evaluasi sediaan gel dengan konsentrasi ekstrak 25% menunjukkan karakteristik yang baik dan sesuai dengan standar sediaan topikal. Evaluasi sediaan gel yang dilakukan meliputi pemeriksaan pH, organoleptik, homogenitas, dan daya sebar. Hasil analisis statistik menggunakan One way ANOVA menunjukkan terdapat perbedaan yang bermakna (P<0,05) antara konsentrasi ekstrak yang digunakan dalam sediaan gel dengan penghambatan pertumbuhan bakteri penyebab jerawat Propionibacterium acnes.
The levels of flavonoids and total phenolics contained in the methanol, 70% ethanol, and ethyl acetate extracts of Bungur leaves (Lagerstroemia speciosa) will be reported in this study. In addition, the antioxidant activity of each extract was also tested. The Bungur leaves (Lagerstroemia speciosa (L) pers) is a plant used empirically as medicine. The preparation and preparation of the extract was carried out by the maceration method, which used three different variations of solvents, including methanol, 70% ethanol, and ethyl acetate. The type of coating and the polarity of the coating significantly affect the antioxidant activity obtained. The phytochemical screening test was carried out to determine the content of chemical compounds in plant extracts. In contrast, the control of flavonoid levels and total phenolic content was carried out using the colorimetric method. Measurement of antioxidant activity levels was carried out using the DPPH test. The qualitative phytochemical screening test results of the methanol, 70% ethanol, and ethyl acetate extracts had the same secondary metabolite content. Still, the highest total flavonoid and phenolic content were found in the methanol extract of Bungur leaves, 9.06% and 16.42%. The antioxidant activity test of the methanol extract of Bungur leaves also showed the best inhibition results, as indicated by the IC50 value of 5.76 ppm. This can strengthen the total phenol and flavonoid levels correlated with antioxidant activity.
Introduction: Transmission of infectious diseases cannot be separated from the interaction between the causative agent of the disease host and the environment. Efforts to increase the host's immune system to survive infectious attacks are also important things to do, including the use of Family Medicinal Plants (TOGA). Family Medicinal Plants (TOGA) are nutritious plants planted in the house’s yard and managed by the family Objective: The problem faced today is the availability of herbal plants in the yard that has not been utilized. Method: This community service was carried out with residents of RW 07 Cawang, with 28 people participating in the activity. Community service is carried out using presentation methods, providing information through flayers, workshops for making herbal drinks, and question-and-answer discussions. Result: The questionnaire results showed that 28 participants (100%) had ever drunk traditional drinks but 11 participants (39.30%) did not know how to make traditional products. Conclusion: The results obtained are that the service participants have the ability of herbal plants to become beverage products that can increase endurance.
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