Binuclear rhodium(II) complexes [Rh2Cl2(μ-OOCR)2(N-N)2] {R = H, Me; N-N = 2,2'-bipyridine (bpy), 1,10-phenanthroline (phen)} and [Rh2(μ-OOCR)2(N-N)2(H2O)2](RCOO)2 (R = Me, Et;) have been synthesized and their structure and properties have been studied by electronic, IR and 1H NMR spectroscopy. Antibacterial activity of these complexes against Escherichia coli and Staphylococcus aureus has been investigated. The most active antibacterial agents against E. coli were [Rh2Cl2(μ-OOCR)2(N-N)2] and [Rh2(μ-OOCR)2(N-N)2(H2O)2](RCOO)2 {R = H and Me} which were considerably more active than the appropriate nitrogen ligands. The complexes show low activity against S. aureus. The activity of the complexes [Rh2(OOCR)2(N-N)2(H2O)2](OOCR)2 against E. coli decreases in the series: R=H≅CH3>C2H5>C3H7≅C4H9. The reverse order was found in the case of S. aureus.

INTRODUCTION. Among the population of adults, hearing loss related to occupational exposure to noise makes up ca 16%, which is the second etiological factor, after ageing, causing anomalies connected with hearing. According to statistical data, in Europe about 30 million of employees are exposed to the noise. In Poland the number equals to 187 500. AIM. The analysis of the structure of confirmed cases of occupational hearing loss between 2008-2017 in Poland and in Podkarpackie Voivodeship. METERIALS AND METHODS. Information related to Podkarpackie Voivodeship was obtained out of the cards verifying occupational illness, sent by National Sanitary District Inspectors from particular districts of Podkarpackie Voivodship to Podkarpacki National Provincial Sanitary Inspectorate. The data related to Poland within indicated period of time are obtained out of the studies entitled Occupational illnesses in Poland, published by Occupational Health Institute in Łódź. RESULTS. In Poland double permanent hearing loss is decreasing. In Podkarpackie Voivodship, during the analysed period of time, the incidence of recognition of occupational hearing loss was not high, a total of 74 cases, including 1 case when the illness concerned a woman. In most cases the occupational hearing loss caused by the noise in Poland and in Podkarpackie Voivodship was revealed in industrial processing. CONCLUSIONS. Most cases of occupational hearing loss in Poland was diagnosed with the men over 60 years old in Śląskie and Pomorskie Voivodeship, professionally linked to mining, heavy mechanical and metallurgical industry as well as means of transport. In Podkarpackie Voivodeship the increased number of diagnosed cases revealed in districts: stalowowolski, krośnieński, rzeszowski and przemyski (metallurgical and timber industry).

INTRODUCTION. In Europe data concerned with occupational exposure to carcinogens or mutagenic factors is collected on the basis of: national registers, databases and information systems related to the exposure, and presenting the degree of health hazard for the employees who are exposed to such factors. The overriding carcinogenic factors at workplace, which are essential for preventive measures against occupational diseases used by institutions responsible for occupational safety, are e.g.: asbestos, polycyclic aromatic hydrocarbons, arsenic trichloroethylene, tetrachloroethylene and industrial processes related to exposure to wood dust. AIM OF THE PAPER. The paper shows current data relating to cancers of occupational origin in Podkarpackie voivodeship between 2003-2019. MATERIAL AND METHODS. The materials coming from Podkarpackie voivodeship between 2003-2019 are collected occupational diseases identification cards, sent to the Podkarpacki National Provincial Sanitary Inspectorate by Sanitary Inspectors of Podkarpackie voivodeship districts. RESULTS. Between 2003 – 2019 in Podkarpackie voivodeship neoplastic diseases made up 1,94% of a total of all occupational diseases. Since 2006 the frequency of the occupational cancers stays at similar level. The most frequent locations of neoplastic diseases of occupational etiology were: lungs, bronchi and larynx. CONCLUSIONS. Occupational cancer can be prevented by elimination or limitation of occupational exposition to carcinogenic or mutagenic substances, regular monitoring of their intensity in work environment, providing workers with individual protection by employers, preventive measures taken by occupational health service, occupational safety and health as well as supervising institutions such as National Sanitary Inspectorate and State Labour Inspectorate.

It has been epidemiologically established that the rate of primary cholangiocarcinomas increases greatly in the ObIrtysh basin which is hyperendemic for helminth Opisthorchis felineus in comparison with other regions where the population is not infested. In this connection chronic opisthorchiasis is considered as facultative liver precancer. The study of cholangiocarcinogenesis mechanisms will allow developing pathogenetic approaches to prevention of this tumor. Aim of the study was to investigate the significance of microbiota of the hepatobiliary tract of chronic opisthorchiasis patients in changing of biochemical composition of bile and investigation of its biological influence on somatic cells membrane. Material and methods. Objects of research: bacteria; inbred mice infected by opisthorchis; samples of bile, cultures of human embryo fibroblasts and splenocytes of inbred mice in vitro; blood plasma; standard primary and secondary bile acids. We studied: species of bacteria colonizing bile ducts; quantitative and qualitative composition of bile acids, and level of diene conjugates and malondialdehyde in duct bile samples; biological activity of bile on processes of lipid peroxidation of cell membranes in vitro; influence of bile and lipid peroxidation products on cytomembrane permeability; activity of antioxidant systems of the body. Results and discussion. It was found out, that bile of patients with chronic opisthorchiasis in majority of cases (77.0 %) was infected by different species of bacteria. In 30.0 % of cases certain types of intestinal bacteria (Proteus vulgaris, P. mirabilis, Citrobacter freundii, Bacteroides alcaligues faecalis, Clostridium, Streptococcus faecalis, Escherichia coli) change biochemical composition of duct bile – deconjugated primary and secondary bile acids and also high level of total bile acids are detected. Bile of the above biochemical composition, against the background of depletion of antioxidant system, induces activation of cell membrane lipid peroxidation processes and significantly increases their permeability to toxic components of bile. These processes are promotor in cholangiocarcinogenesis.