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Ayurveda is the most ancient system of life, health and cure. It is highly evolved and codified system of life and health science, based on its own unique and original concepts and fundamental principles. Rasa shastra, which starts with a pledge to render a happy, healthy and prosperous life can be considered as an advanced stage of Indian system of medicine. Rasa shastra has large number varieties of Rasaushadhi aiding on Madhumeha (Diabetes Mellitus) but among them ‘Indra Vati’ is one of the significant ones. Though this preparation is not formulated by any pharmacy. CCRAS and DPT. of AYUSH declared standards for some Ayurvedic drugs and formulations in Ayurvedic Pharmacopoeia of India but there is no matter regarding standards of Indra Vati found in it. So, here an attempt has been made to see all the factors are integrated and a strategic approach to validate such a process for Indra vati preparation and Standardization in terms of Ayurvedic as well as Modern science and technology.