Background: One of the medication attempts in diabetes mellitus is by utilising plants that are potent as an antioxidant. Eurycoma longifolia Jack. known as "Longjack" in English, is a medicinal plant and reportedly effective as an antioxidant. Objectives: This study was aimed to examine the antidiabetic effectiveness of ethanol extract of longjack leaf in diabetes mellitus rats. Methods: This study used the total of 24 male white rats which were grouped into four. The normal and the negative control groups were administrated with CMC-Na 0.5% dose 2 ml/200 g body weight; one group was administrated with ethanol extract of longjack leaf dose 176.4 mg/200 g body weight; and the positive control group was administrated with glibenclamide dose 0.09 mg/200 g body weight. Before the extract administration, all of the experimental animals were prior induced into diabetic condition with streptozotocin-nicotinamide. Results: The levels of blood glucose and malondialdehyde in rats after the 14-day extract treatments were 78.73 mg/dl and 1.13 nmol/ml, respectively in the normal control group; 285.84 mg/dl and 10.03 nmol/ml were in the negative control group; 156.77 mg/dl and 3.86 nmol/ml in the group with the administration of ethanol extract of longjack leaf; and 148.63 mg/dl dan 3.64 nmol/ml in the group of glibenclamide administration (p<0.05). The reduction of blood glucose and malondialdehyde levels in the groups of ethanol extract administration of longjack leaf dose 176.4 mg/200 g body weight was similar to the glibenclamide administration dose 0.09 mg/200 g body weight. Conclusion: The ethanol extract of longjack leaf was effective as an antidiabetic.

<p class="StyleAuthorBold"><strong>Abstrak</strong></p><p>Penelitian bertujuan mengetahui kelayakan video sebagai media pembelajaran pada submateri Sistem Endokrin kelas XI SMA. Penelitian menggunakan metode penelitian deskriptif. Tahapan penelitian meliputi tahap penyusunan materi isi media video dan validasi media video. Validasi dilakukan oleh lima validator. Instrumen penelitian menggunakan lembar validasi. Penilaian lembar validasi menggunakan skala Likert. Aspek yang dinilai yaitu aspek format, isi, dan bahasa. Data dianalisis menggunakan formula Lawshe. Hasil validasi menunjukkan rata-rata CVR pada aspek penilaian format, isi, dan bahasa lebih besar dari batas minimum Lawshe. Berdasarkan hasil penelitian, maka disimpulkan bahwa media video dapat digunakan sebagai media pembelajaran pada submateri Sistem Endokrin pada kelas XI SMA.</p><p> </p><p class="StyleAuthorBold"><strong><em>Abstract</em></strong></p><p><em>The research aimed to determine the feasibility of video as a learning medium in the Endocrine System submaterial in class XI senior high school. The research used descriptive method. The research stages include the stage of compiling the video media content material and the video media validation stage. Validation was carried out by five validators. The research instrument used a validation sheet. The validation sheet assessment used a Likert scale. The aspects that assessed were format, content, and language. Data were analyzed using Lawshe's formula. The validation results showed that the average CVR in the aspect of format, content, and language assessment was greater than the Lawshe minimum limit. Based on the results of the study, it can be concluded that video media can be used as a learning medium in the Endocrine System submaterial in class XI senior high school.</em></p>

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