Gastrointestinal lymphoma accounts for up to 20% of all extranodal lymphoma cases. Among them, the ileum is the second most commonly affected site after the stomach. The majority of gastrointestinal lymphoma originates from the B cell lineage. We report the case of 60-year-old male with persistent anemia, hematochezia, and poor performance status (PS). After thorough workup, imaging, and pathological study, the patient was diagnosed with diffuse large B-cell lymphoma of the terminal ileum. He was treated with R-CHOP based chemotherapy with dose tailoring to accommodate his poor PS. His symptoms promptly subsided after the first chemotherapy cycle. After eight cycles of chemotherapy, terminal ileum wall thickening was gone and the patient was disease-free for 6 months. This case report shows that chemotherapy can be beneficial in patients with gastrointestinal lymphoma despite poor PS. Therefore, it should be given when possible with proper dose tailoring.

Coronavirus Disease 2019 (COVID-19) is a respiratory infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. COVID-19 spreads very quickly to various countries and causes a high mortality rate. According to this urgency, a study was conducted on albumin levels, mean platelet volume (MPV), and neutrophil-lymphocyte ratio (NLR) as predictors of COVID-19 outcome. This research was an analytic observational study conducted cross-sectional at Dr. Moewardi Hospital Surakarta, Indonesia, from June-October 2021. Data analysis used the logistic regression test and ROC analysis to determine the cut-off point for each variable. The total samples used in this study were 123 samples, with 68 survival patients and 55 nonsurvival patients. Logistic regression test results received p values for MPV and NLR, respectively, 0.048 and 0.001, and OR values 1.369 and 1.186 with Nagelkerke R Square 0.186. The cut-off point of MPV is 9.05 (sensitivity 76.4%; specificity 48.5%; p=0.019), and the cut-off point of NLR is 3.27 (sensitivity 92.7%; specificity 55.9%; p=0.001). In conclusion, MPV and NLR can be used as predictors of COVID-19 outcomes.

Abstrak. Coronavirus Disease 2019 (COVID-19) telah menyebabkan masalah kesehatan di seluruh dunia dengan morbiditas dan mortalitas yang terus meningkat. Pada beberapa kasus COVID-19 diketahui terjadi manifestasi trombotik. Adanya kelainan trombotik ini tentunya mempengaruhi tatalaksana dan prognosis pasien COVID-19. Oleh karena itu penting untuk mengetahui patofisiologi dan manajemen trombosis pada COVID-19. Tujuan dari artikel ini adalah mengulas literatur terbaru terkait prevalensi, patofisiologi, penilaian risiko, serta manajemen trombosis pada COVID-19.Kata kunci: COVID-19, trombosis.Abstract. Coronavirus Disease 2019 (COVID-19) has become a global health problem with ever increasing morbidity and mortality. In some cases, thrombotic manifestation has been reported in COVID-19 patients. This thrombotic manifestation certainly affects the management and prognosis of COVID-19 patients. Therefore it is crucial to understand the pathophysiology and management of thrombosis in COVID-19. The aim of this article is to review the recent literature regarding prevalence, pathophysiology, risk assessment, and management of thrombosis in COVID-19.Keywords:COVID-19, thrombosis

No abstract