Aspirin has low solubility in water therefore, dissolution is a rate limiting step for absorption. Floating tablet formulation is designed to improve the bioavailability of aspirin. The objective of this study was to determine in vitro dissolution study of aspirin floating tablet release kinetics model. The floating tablets were prepared by a direct compression method using Methocel K4M CR, NaHCO 3 , Ethocel, Aerosil, and dicalcium phosphate anhydrous as excipients. Tablets were evaluated by different parameters such as physicochemical properties, floating lag time (F lag time ), total floating time, and dissolution. The result showed that the tablet mass has good flow properties of 13.54 g/sec. Aspirin floating tablets had a weight uniformity (CV=1.45%), good hardness (6.42kg), and low friability (0.158%). The tablet has a short F lag time of 25.16 sec and long floating time of 8 hours. Dissolution data were evaluated using DDSolver conducted by (1) Statistical parameters: R 2 adjusted , AIC, MSC; (2) Visual goodness of fit (GOF). The results showed that aspirin floating tablets release kinetics followed the Korsmeyer-Peppas model. Aspirin release occurs through the mechanism of anomalous transport which combines Fickian diffusion and polymer relaxation.

Water tracing was conducted at Karangbolong Karst as a rapid assessment of the Kalisirah spring hydrological characteristics. This study was conducted to determine the movement of underground flow and the estimation of the Catchment Area using the Todd Nomogram and field observations. The results of flow tracing tests conducted in Pocung Cave indicate that there is underground river network connectivity between Pocung Cave, Jeblosan Sinkhole and Kalisirah Springs. Based on topographic survey and flow tracing test, the calculation of the estimated area of the Kalisirah catchment area is 180 Ha. The results were also validate using other parameters, namely flowrate and rainfall in the research location using Todd Nomogram. The estimated area of the Kalisirah catchment area with the Todd Nomogram is 189.2 Ha. The calculation of the estimated area of Kalisirah catchment area based on topographic survey and water tracing is relevant with the estimated area with Todd Nomogram. Groundwater tracing investigation can be used to determine karst spring catchment area, as a preliminary study to understanding the karst hydrology.

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The distribution of pharmacies in Indonesia is still becoming a problem. Pharmacies are mostly available around healthcare facilities such as hospitals, service providers, trade centers, transportation facilities, and main roads. The study aims to describe the distribution profile of pharmacies based on Geographic Information System (GIS) analysis and to study the relation between pharmacy distribution profiles with the number of consumer visits and prescriptions. The study is conducted in 27 sub-districts in Banyumas Regency, Central Java using Arc Gis 3.10.2 Software. Pharmacy profile, the number of consumer visits, and prescriptions at the pharmacy are obtained by distributing research questionnaires to pharmacists. The results showed that the distribution of pharmacies in the Banyumas Regency was still dominant in urban areas, which reached 55%. The average distance of pharmacies was 2.34 km. The research results on the distribution pattern of pharmacies in 27 sub-districts showed that in 3 districts (11.1%) were grouped in certain areas, in 24 other districts (88.9%), the pharmacies' distribution had a spread distribution pattern. The conclusion of the research that the distribution of pharmacies in the Banyumas Regency based on GIS visualization was still dominant in urban areas and especially in sub-districts around the capital of Banyumas Regency, Purwokerto. Based on the study, there was a relation between the average distance of pharmacies and the number of healthcare facilities on consumer visits. There was a relation between pharmacy density, population density, and the number of healthcare facilities with the number of prescriptions.