Local anesthetics are drugs widely used to perform peripheral nerve blocks. Signs and symptoms of toxicity may vary from mild to severe, including neuro and cardiotoxicity, with seizures and cardiac arrest. We present the case of an 85-year-old patient in total left knee replacement plan due to tibial saucer fracture, where systemic toxicity was observed by local anesthetics (LAST) after performing a femoral nerve block guided by neurostimulation and ultrasound with a solution of 20 ml of 0.525% ropivacaine + 0.6% lidocaine. As a positive data, the patient presented severe hypoalbuminemia rESumEN Los anestésicos locales son fármacos ampliamente utilizados para realizar bloqueos nerviosos periféricos. Los signos y síntomas de toxicidad pueden variar de leves a severos, incluidas la neuro y cardiotoxicidad, con convulsiones y paro cardíaco. Presentamos el caso de una paciente de 85 años de edad en plan de reemplazo total de rodilla izquierda debido a fractura de platillo tibial, donde se observó toxicidad sistémica por anestésicos locales (LAST por su sigla en inglés) después de realizar un bloqueo del nervio femoral guiado por neuroestimulación y ultrasonido con una solución de 20 ml de ropivacaína al 0,525% + lidocaína al 0,6%. Su único antecedente médico era presentar hipoalbuminemia severa.
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