Carbamide and hydrogen peroxide are the most frequently utilized compounds for various whitening techniques, that differ as per peroxide level, method of administration, and exposure period, when it comes to the active solutions accessible for important tooth whitening. The 10±1% carbamide peroxide dosage was the only level to date to acquire the American Dental Association's stamp of approval, ensuring its safety and effectiveness for at-home tooth whitening with customized trays. There has been a noticeable growth in the range of in-office tooth whitening compounds commercially available, which typically use elevated carbamide peroxide levels (30 to 37%) with or without an additional illumination. Even though tooth sensitivity appears to be the most frequent side effect of carbamide peroxide bleaching, discomfort goes away when the plan of care is finished. Sensitivity is typically linked to a background of sensitive teeth, greater administration rate, or use of greater carbamide peroxide levels. Additionally, studies have showed that using 10% carbamide peroxide at home to lighten teeth had comparable effectiveness to other methods (over the counter or in-office whitening). Patients generally prefer home vital bleaching with 10% carbamide peroxide to office procedures with 35% hydrogen peroxide. When comparing the safety utilizing 16% carbamide peroxide for nightguard vital bleaching to a placebo or 10% carbamide peroxide, patients receiving 16% reported higher gingival soreness than those administered a 10% carbamide peroxide or a placebo.